Tocotrienols have been reported to have superior antioxidant and anti-thrombotic activity. Derived from annatto from the achiote trees of tropical regions of the Americas, tocotrienols work together in the human body with tocopherols (vitamin E).

But tocotrienols and tocopherols should not be combined together in a supplement and taken together because tocopherols hinder the assimilation of tocotrienols. Rather, take them separately. For example, the tocopherol vitamin E could be taken in the morning and tocotrienol in the evening.